The Second Noble Truth: The Arising of Duhkha. The origination of Duhkha, or dissatisfaction, frustration, or suffering, emerges from a general human characteristic as “Three Poisons:” (a) self-centered craving or attachment-desire for sense of pleasures; power,money, beliefs (absolute truth); (b) envy, anger, or hatred; and (c) confusion or ignorance of the nature of reality.