Our case is only the second reported instance whereby life-threatening uterine hemorrhage in an AML patient was resolved using bilateral uterine artery embolization. The first was in 1983 in a woman with intractable uterine bleeding after presenting with APL and an incomplete spontaneous abortion. As in our case, she obtained prompt relief from uterine hemorrhage with bilateral uterine artery embolization despite pre-procedural blood losses of 4 L per day. Retrospectively in the case reported herein it is likely that earlier intervention with this technique may have substantially altered her clinical course in terms of shortened duration of MICU stay and minimizing exposure of this potential allogeneic transplant recipient to large quantities of heterologous blood products. Although life-threatening uterine bleeding in AML patients is relatively rare this case should be illustrative of how a relatively mildly invasive therapeutic intervention may be both life-saving and cost effective.