The final product (F) goes back to react with the first
enzyme thereby inhibiting further reaction since it is not
the starting material for the process. Hence, the enzyme
E1 becomes incapable of accommodating any other substrate until F leaves and F
can only leave if the body utilizes it. If the body cannot utilize the product formed from
the heavy metal – protein substrate, there will be a permanent blockage of the enzyme E1,
which then cannot initiate any other bio-reaction of its function.
Therefore, the metal remains embedded in the tissue, and will result
in bio-dysfunctions of various gravities (Holum, 1983).