We next surveyed the role of ABC transporters in the transport of xenobiotics/plant allelochemicals
and their involvement in insecticide resistance. The involvement of ABC transporters in
xenobiotic resistance in arthropods is historically not well documented, but an increasing number of
studies using unbiased differential gene expression analysis now points to their importance. We give an
overview of methods that can be used to link ABC transporters to resistance. ABC proteins have also
recently been implicated in the mode of action and resistance to Bt toxins in Lepidoptera. Given the
enormous interest in Bt toxicology in transgenic crops, such findings will provide an impetus to further
reveal the role of ABC transporters in arthropods.
2014 The Authors. Published by Elsevier Ltd. All rights reserved