4. Conclusion
In this paper, a novel, efficient and nano-sized BPA-imprinted silica sorbent was synthesized by a surface imprinting technique. The BPA-imprinted silica nanoparticles showed high adsorption capacity and selectivity, and offered a fast kinetics for the rebind- ing of BPA. The MIP-SPE and HPLC method showed more efficient clean-up of BPA from shampoo, bath lotion and cosmetic cream samples than traditional C18-SPE and HPLC method. Also the MIP- SPE and HPLC method could provide satisfactory recoveries and reproducibility.
It has clearly indicated that the combination of nanotechnique with molecular imprinting technique can significantly improve the binding capacity and kinetics. Although the current work is mainly focused on the imprinting of BPA molecules, the experimental results demonstrate that the silica nanostructure with imprinting technique is an ideal approach for the imprinting of various organic or biological molecules. It is competent to be exploited in concen- tration and purification of trace analytes in the complex matrix.