Cell-based biosensors, which provide a variety of biologically active information for analytes allow
for the monitoring of cytotoxic effects in response to dangerous substances, as well as the
physiological cell response to numerous stimuli. Therefore, living cells are utilized as their biocontents, and the activity of living cells can be electrochemically monitored in a cell-based biosensor
system. With these benefits, cell-based sensor systems have been considered as a promising
technology for biomedical and pharmacological applications [93]. In particular, increasing attention
has been paid to the integration of live cells with silicon-based FET devices. Above all, cell-based
ISFET biosensors are of great interest for upcoming applications in the area of neuronal network and
transmission paths of ionic channels.