Nonsteroidal antiinflamatory drug (NSAIDs) are the first drugs used. Naproxen, ibuprofen, and tolmetin are approved for use in children. They are effective with few common side effects other than gastrointestinal irritation and bruising; with naproxen, skin fragility is a possible side effect. NSAIDs must be taken with food. Aspirin, once the drug of choice, has been replaced by NSAIDs because they have fewer side effects and easier administration schedules.