The updated guideline then underwent Guideline Implementability
Appraisal, to appraise adherence to methodologic
standards, to improve the clarity of recommendations, and to
predict potential obstacles to implementation. The final draft
of the updated clinical practice guideline underwent extensive
external peer review. Comments were compiled and reviewed
by the group chairperson. The recommendations contained
in the guideline are based on the best available published
data through October 2012. Where data were lacking, a