HCV is an enveloped positive-stranded RNA virus that belongs to the Flaviviridae family. The viral
genome is translated into a polypeptide, which is sequentially processed into ten mature proteins
(Figure 1). The structural proteins core and the envelope proteins (E1 and E2) lie at the N-terminus of
the polyprotein. The non-structural proteins NS3, NS4A, NS4B, NS5A and NS5B are located at the
C-terminus. Between the structural and the non-structural proteins are two proteins most likely
non-structural (p7 and NS2), which are dispensable for replication, but essential for assembly [8].
HCV is an enveloped positive-stranded RNA virus that belongs to the Flaviviridae family. The viral
genome is translated into a polypeptide, which is sequentially processed into ten mature proteins
(Figure 1). The structural proteins core and the envelope proteins (E1 and E2) lie at the N-terminus of
the polyprotein. The non-structural proteins NS3, NS4A, NS4B, NS5A and NS5B are located at the
C-terminus. Between the structural and the non-structural proteins are two proteins most likely
non-structural (p7 and NS2), which are dispensable for replication, but essential for assembly [8].
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