Two common examples are
ischemia and toxic injury. For example, carbon monoxide poisoning and
probably other mitochondrial toxins can result in delayed neuronal death
through apoptosis.
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Such environmental injury may interact with genetic
factors to result in neurodegenerative disease in late life. Thus, a further
category of neurodegenerative disease can be characterized as having a
secondary or environmental relationship to apoptosis.
neutral or “normal” host can result in apoptosis.