Absence of good animal models for testing of human intestinal sickness antibodies, the challenges in assessment of viability of the immunization in endemic regions, and the absence of comprehension of the immunosuppressive systems of the parasite are the preeminent explanations behind the disappointment of a powerful immunization. The utilization of murine models to exhibit hearty insurance has neglected to stand valid in most human trials. One of the conceivable purposes behind the same is on the grounds that we utilize unnatural rat has, and not the regular host (tree shrews) of the murine malaria.