The need for a treatment strategy in Uganda, which rapidly and adequately treats MDR-TB and HIV has been highlighted elsewhere, with one study finding the retreatment approach to TB to be unsatisfactory [22]. Our study is the first to assess the acceptability of a model of home-based treatment and care for MDR-TB for patients and staff. However, this is complemented by several studies examining community-based models of treatment for DS-TB and MDR-TB in multiple settings, including Uganda. These show community or home-based treatment to be effective, feasible and safe [6-8] as well as supportive of adherence [23].