While substantial progress has been made in breast
cancer genetics over the last two decades, further largescale studies integrating both genome and transcriptome
analyses [72] are needed to identify the key oncogenic
driver genes or other specific biomarkers. The potential
new findings could be of predictive values for diagnosis,
predicting metastasis, survival assessment, and guiding
targeted therapy. FISH can be of particular value in both
the discovery and clinical routine detection of such biomarkers and will continue to play an important role in
the personalized management of breast cancer