Histopathologic findings
All cases (except case 6, which represented contamination) showed granulation and fibrous tissue with a variable lymphoplasmacytic infiltrate consistent with a healing wound. In all cases, there were hyalinized eosinophilic strands of fibrillar material resembling collagen (Figures 2 and 3). Some of the eosinophilic strands were present in a meshwork, or as thinner, more delicate fibrils appearing to be in the process of disintegration (Figure 4, A, B); these fibrils were separated by fibrous connective tissue containing fibroblasts with scattered lymphocytes. A foreign body giant cell reaction was not seen. The collagen membrane differed from the surrounding collagen because of its lack of cellularity (Figure 5). However, it was refractile in a fashion similar to collagen (Figure 6). It also stained positively with the Masson trichrome stain (Figure 7). There was no evidence of osteoid or woven bone formation in any of the cases.
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Histopathologic findings
All cases (except case 6, which represented contamination) showed granulation and fibrous tissue with a variable lymphoplasmacytic infiltrate consistent with a healing wound. In all cases, there were hyalinized eosinophilic strands of fibrillar material resembling collagen (Figures 2 and 3). Some of the eosinophilic strands were present in a meshwork, or as thinner, more delicate fibrils appearing to be in the process of disintegration (Figure 4, A, B); these fibrils were separated by fibrous connective tissue containing fibroblasts with scattered lymphocytes. A foreign body giant cell reaction was not seen. The collagen membrane differed from the surrounding collagen because of its lack of cellularity (Figure 5). However, it was refractile in a fashion similar to collagen (Figure 6). It also stained positively with the Masson trichrome stain (Figure 7). There was no evidence of osteoid or woven bone formation in any of the cases.
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