People living with HIV in regions where TB prevalence
is high are at a higher risk of Mycobacterium tuberculosis
infection, often progressing to active TB disease, and in turn
to rapid and severe immunological compromise. Thereafter,
people living with HIV can die of TB as well as other
AIDS-related opportunistic infections (AOI). Intolerance
to multiple drug regimens and adverse drug interactions
are other untoward effects of TB treatment that can lead to
severe liver injury and death.