tInfluenza A virus infects the human respiratory system and causes acute and fatal pulmonary diseases The emergence of drug-resistant viral strains highlights the need for alternative therapeutic approaches.In this work With inactivated whole H1N1 virus Western blotting and thehemagglutination inhibition (HI) test demonstrated that the IgY antibody could specifically bind theneuraminidase and hemagglutinin of the H1N1 virus. In the plaque reduction assay In a mouse model Theseresults demonstrated that IgY can be easily produced and can offers an effective alternative approach forinfluenza control