The lignan nordihydroguaiaretic aci

The lignan nordihydroguaiaretic acid (NDGA) and its derivatives existing in Larrea divaricata species show
a wide range of pharmacological activities which makes this genus an interesting target to consider the
plant in vitro cultivation systems as a feasible alternative source for their production. These compounds
are potentially useful in treating diseases related to heart condition, asthma, arteriosclerosis, viral and
bacterial infections, inflammation and cancer. In the present study, calli, cell suspension cultures, and
in vitro and wild plants of L. divaricata were investigated for their potential to synthesize phenolic compounds.
Calli, both with and without organogenesis, produced NDGA and quercetin, as did plantlet and
wild plants. NDGA was also produced by the cell suspension cultures, together with p-coumaric acid,
ferulic acid and sinapyl alcohol. The capacity of undifferentiated tissues to form phenolic compounds is
very limited, but when the calli underwent organogenesis, developing mainly adventitious shoots, the
phenolic compound production increased significantly. Plantlets regenerated from adventitious shoots
of L. divaricata calli did not show the same phenolic pattern as wild plants, with levels of NDGA and
quercetin being 3.6- and 5.9-fold lower, respectively.

ผลลัพธ์ (ลาว) 1:

ອາ​ຊິດ lignan nordihydroguaiaretic (NDGA​) ແລະ​ອະ​ນຸ​ພັນ​ຂອງ​ຕົນ​ທີ່​ມີ​ຢູ່​ແລ້ວ​ໃນ Larrea ຊະ​ນິດ divaricata
ສະ​ແດງ​ໃຫ້​ເຫັນ​ເປັນ​ລະ​ດັບ​ຄວາມ​ກ​້​ວາງ​ຂອງ​ກິດ​ຈະ​ກໍາ​ການ pharmacological
ທີ່​ເຮັດ​ໃຫ້​ສະ​ກຸນ​ນີ້​ເປັນ​ເປົ້າ​ຫມາຍ​ທີ່​ຫນ້າ​ສົນ​ໃຈ​ທີ່​ພິ​ຈາ​ລະ​ນາ​ຂອງ​ພືດ​ໃນ​ລະ​ບົບ​ການ​ປູກ​ຝັງ vitro ເປັນ​ແຫຼ່ງ​ທາງ​ເລືອກ​ທີ່​ເປັນ​ໄປ​ໄດ້​ສໍາ​ລັບ​ການ​ຜະ​ລິດ​ຂອງ​ເຂົາ​ເຈົ້າ​. ທາດ​ປະ​ສົມ​ເຫຼົ່າ​ນີ້​ມີ​ທ່າ​ແຮງ​ທີ່​ເປັນ​ປະ​ໂຫຍດ​ໃນ​ການ​ປິ່ນ​ປົວ​ພະ​ຍາດ​ທີ່​ກ່ຽວ​ຂ້ອງ​ກັບ​ສະ​ພາບ​ຫົວ​ໃຈ​, ພະ​ຍາດ​ຫືດ​, ເສັ້ນ​ເລືອດ​ອຸດ​ຕັນ​, viral ແລະ​ພະ​ຍາດ​ຊຶມ​ເຊື້ອ​ແບັກ​ທີ​ເລຍ​, ການ​ອັກ​ເສບ​ແລະ​ມະ​ເຮັງ​. ໃນ​ການ​ສຶກ​ສາ​ໃນ​ປະ​ຈຸ​ບັນ​, ກໍ​ຕາມ​, suspension ມື​ຖື​ວັດ​ທະ​ນະ​ທໍາ​, ແລະ​ໃນ vitro ແລະ​ພືດ​ປ່າ​ຂອງ L. divaricata ໄດ້​ຮັບ​ການ​ສືບ​ສວນ​ສໍາ​ລັບ​ທ່າ​ແຮງ​ຂອງ​ເຂົາ​ເຈົ້າ​ການ​ສັງ​ເຄາະ​ທາດ​ປະ​ກອບ​ຟີ​. Calli​, ທັງ​ທີ່​ມີ​ແລະ​ບໍ່​ມີ organogenesis​, ການ​ຜະ​ລິດ NDGA ແລະ quercetin​, ເຊັ່ນ​ດຽວ​ກັບ plantlets ແລະ​ພືດ​ປ່າ​ທໍາ​ມະ​ຊາດ . NDGA ມີ​ການ​ຜະ​ລິດ​ໂດຍ​ວັດ​ທະ​ນະ​ທໍາ suspension ສັບ​ມື​ຖື​, ພ້ອມ​ດ້ວຍ​ອາ​ຊິດ p​, coumaric​, ອາ​ຊິດ ferulic ແລະ​ເຫຼົ້າ sinapyl​. ຄວາມ​ອາດ​ສາ​ມາດ​ຂອງ​ແພ​ຈຸ​ລັງ​ແຕກ​ຕ່າງ​ທີ່​ຈະ​ປະ​ກອບ​ທາດ​ປະ​ກອບ​ຟີ​ແມ່ນ​ຈໍາ​ກັດ​ທີ່​ສຸດ​, ແຕ່​ວ່າ​ໃນ​ເວ​ລາ​ທີ່ Calli ທີ່ underwent organogenesis​, ການ​ພັດ​ທະ​ນາ​ຫນໍ່ adventitious ສ່ວນ​ໃຫຍ່​, ການ​ຜະ​ລິດ​ທາດ​ປະ​ກອບ​ຟີ​ເພີ່ມ​ຂຶ້ນ​ຢ່າງ​ຫຼວງ​ຫຼາຍ​. plantlets ການ​ຟື້ນ​ຟູ​ຈາກ​ຍອດ adventitious ຂອງ Calli divaricata L. ບໍ່​ໄດ້​ສະ​ແດງ​ໃຫ້​ເຫັນ​ຮູບ​ແບບ​ຟີ​ເຊັ່ນ​ດຽວ​ກັນ​ກັບ​ພືດ​ທໍາ​ມະ​ຊາດ​, ມີ​ລະ​ດັບ​ຂອງ NDGA ແລະ quercetin ເປັນ 3.6- ແລະ 59 ເທົ່າ​ຕ​່​ໍ​າ​ຕາມ​ລໍາ​ດັບ​.