The research in 2015 of Daily news said that the people who live in urban areas are at risk of vitamin D lack such as, Bangkok have statistics for vitamin D deficiency 64.5% and who lived in the city of Khon Kaen Province lack of vitamin D statistics to 60%. Sukree Soontrapa does research prevalence of Vitamin D Deficiency among Postmenopausal Women at Srinagarind Hospital, Khon Kaen Province, Thailand Found that the prevalence of vitamin D deficiency in postmenopausal women reaches as high as 60.2 percent. Osteoporosis is a major problem of Ministry of Public Health around the world including Thailand. Osteoporosis is a chronic disease of the bone is more common in women of menopause. Osteoporosis is common in female menopause were 80 and ratio of female to male patients with osteoporosis in 4 per 1.