Despite the increasing reported applications of AGS for municipal and industrial wastewater, textile wastewater treatment with this technology has scarcely been reported [14]. Thus, the objective of this work was to assess the applicability of the novel AGS technology in SBR as an alternative to the conventional flocculent activated sludge SBR technology for dyeladen textile wastewater treatment.For that, the performance of two anaerobic/aerobic SBR systems,one with activated sludge flocs and the other with aerobic granules,was evaluated in terms of chemical oxygen demand (COD) and color removal efficiencies in the treatment of a simulated textile wastewater. To our knowledge, this is the first time that such a comparison is performed. In parallel to color and COD removal profiles, the potential detoxification of the simulated textile wastewater during SBR operation was also examined by using yeast-based assays[15,16] with the eukaryotic model Saccharomyces cerevisiae. This is a simple, animal-alternative and relatively inexpensive experimental test system that can provide a fast preview of the potential toxicity of chemicals/effluents meaningful for other eukaryotes[15–17].