The RNA molecular is the basis of violence and pathogenesis of Dengue hemorrhagic fever (DHF) and Dengue Shock Syndrome (DSS) that must to know, to ensure that dengue vaccine development overcome of dengue virus evolution. The mechanisms of dengue vaccine for protection need to be clarified in future. The immunogenic target of immunity response to dengue virus all 4 serotypes at least 80% of volunteers may not be appropriate in all community