An occlusive dressing may facilitate a moist wound environment and retains the wound fluid and its various components; however, it also keep oxygen away from the tissues at the same time. Oxygen plays an important role in the collagen synthesis [38]. One of the important functions of maltodextrin in the wound healing application is the formation of a film, which is intimately adhered to the underlying granulation tissue. This film is semipermeable to gas and fluids, providing an ideal protective cover to reduce the loss of fluid and plasma and invasion by pathogenic bacteria [12]. This finding indicated that our newly produced RB maltodextrins not only enhance the speed recovery rate of wound healing but also are capable of forming a thin protective layer over the wound that subsequently allowed the exchange of oxygen and retaining the required sugars (from maltodextrin) as a nutritious source to the wounded cells for the proliferation of new cells. Even though our study was conducted using in vitro model on NIH 3T3 fibroblast cell, Heng's [38] study had supported our findings and they claimed that sugar dressings (maltodextrin) tested on wounded dogs and cats in a veterinary clinical study capably drew macrophages into the wound and accelerated sloughing of necrotic tissue which enhanced the recovery rate of wound healing process. In addition, their study also reported that the supply of simple sugar to the wounded site acted as a local nutrient source which decreased the incidence of inflammatory edema and subsequently sped up the cell granulation and epithelialization process.