This usually occurs between age 2-12 weeks; however, late-onset vitamin K deficiency bleeding can be seen as long as 6 months after birth.
This disease is most common in breastfed infants who did not receive vitamin K prophylaxis at birth. Vitamin K content is low in mature human milk and ranges from 1-4 mcg/L.
Industrial contaminants in breast milk have been implicated in promoting vitamin K deficiency bleeding.
More than half of these infants present with acute intracranial hemorrhages.[8]