History of angioneurotic oedema. Haemodynamically relevant stenosis of the renal artery, bilateral or unilateral in the single kidney. Hypotension or labile circulatory condition. Co-administration with aliskiren-containing drugs in patients with diabetes or moderate to severe renal impairment. Co-administration with angiotensin II receptor blockers in patients with diabetic nephropathy. Extracorporeal treatments leading to blood contact with negatively charged surfaces. Pregnancy.