Chalcopyrite is the major and most abundant commercial source of copper. It is often accompanied with pyrite, which is the most widespread naturally occurring metal sulfides. The float ability of pyrite is quite similar to chalcopyrite. Pyrite in copper concentrates will not only lower their quality but also increase the economic and environmental costs in the subsequent smelting process. The collecting ability of traditional sulfides collectors is very strong but their selectivity is poor; thus, usually the ideal copper–sulfur separation could not be realized by these collectors. The copper released from chalcopyrite will activate pyrite and increase the difficulty for the separation of chalcopyrite and pyrite as well. There are five common copper–sulfur separation processes, which are known as high pH process, inorganic inhibitors process,organic inhibitors process, electrochemical controlling process and cyanide process. High pH value process is themost widely used process [8,9]. Even though this process couldget prefect flotation and separation result, a large amount oflime must be consumed and the recovery and grade of copper