This study revealed that the presence of E. coli and its pathogenic strains is common in the poultry meat. Such contamination can easily lead to cause the infections related to this bacteria. Its presence in food materials is a problem, while the developments of drug resistance by these common pathogens are more serious matter of concern for food safety and public health. It was concluded that the majority of commonly in use antibiotic are not active against E. coli isolates from poultry meat. New strategies and proper food safety management are needed to prevent the contamination of food materials and to reduce the drug resistance. Developing a new and natural antibiotic with a novel mode of action is necessary for the treatment of such multi-drug resistant bacteria.