In the position paper recently published by the ESPGHAN Committee on Nutrition [15], it was noted that interpreting studies on the effects of probiotic supplementation of infant formula on growth is difficult due to the limited number of studies that analyzed the effects of a given probiotic strain. The studies were often too small with insufficient power to identify relevant effects on growth, and the follow- up periods in the trials were short. Although, in general, it was concluded that a few probiotic strains used to supplement infant formula support normal growth in healthy term infants, this conclusion needs to be considered with caution. The same caution applies to other outcomes.