Cysticercosis is widely prevalent in Latin America, Asia, and parts of Africa; ≈50 million persons are infected globally (2,3). The disease is routinely seen in the United States in immigrants from disease-endemic regions, particularly Latin America (4,5). Recent attention has focused on cysticercosis as one of the neglected infections associated with poverty in the United States and also as a major cause of preventable epilepsy (6). The relevance of this parasitic infection as a public health problem in the United States has been highlighted by reports of autochthonous cases (7). This phenomenon was underscored by Schantz et al. in their report of an outbreak of cysticercosis in an Orthodox Jewish community in New York City in 1990–1991 (8). Several other publications, particularly over the past 25 years, have documented cysticercosis acquired in the United States (5,7–25). We present an aggregation of these published reports and discuss the attendant public health issues, including policy implications and approaches to prevention.