This research is designed biomedical signal based driver monitoring system. In the device consists of two parts: 1.Wearable Wrist, measure heart rate and temperature of body. 2. Device on the seat belt, measure respiration rate. The signal detect with sensor installed on the place, processed in real time. All sensors are stored in the packet, it convenient for installation and saving space. Then the signal is analyzed to determine conditions. If subject live in a state of drowsiness, the system will alarm with voice to motivate the driver awake. This system can be used for the general public because it was development to cheap.