DM type 2 :
1st phase insulin secretion : abolish
Late phase : reduce & delay.
Early phase insulin secretion
-suppress hepatic glucose production & lipolysis
-cross endothelial barrier
-prepare target cells to the action of insulin
Decrease in 1st phase in early of the disease :
-Impaired glucose tolerance(IGT)
-Normoglycaemia 1st degree relatives (DM type 2)