Ninety percent of deaths from mushroom ingestions are due to amatoxin, which possesses a fatality rate of up to 25% when ingested. In 2007, 45 cases of amatoxin poisoning were reported in the United States, with only one documented death. The difficulty in the treatment of amatoxin poisoning lies in part to the lack of both an effective antidote and a standardized accepted treatment for this poisoning. On a molecular level, amatoxin and its effects on downstream physiologic targets is just beginning to be understood, thus leading to the lack of progress in therapeutic options for amatoxin poisoning [1]. The majority of reported amatoxin ingestions fall in a few specific categories, such as accidental ingestions in young children or wild mushroom foragers and intentional ingestions in patients attempting suicide or seeking the drug for its hallucinatory affects [1].