There are currently multiple large clinical trials looking at EGDT in the treatment of severe sepsis/septic shock. The ProCESS (Protocolized Care for Early Septic Shock) Trial and The ProMISe (Protocolized Management in Sepsis) Trial (funded, however not yet enrolling patients) are two examples 37 and 38. These studies may further our understanding of specific EGDT components and the role of invasive procedures in management.