Hypromellose ointment is ahydrophilic ointment possessing good adhesive properties to wettedsurfaces. The vehicle (sterile) was mixed with the C. citratus oil underaseptic conditions to obtain the desired concentrations using a mortarand a pestle. Sterilized silicone rubber pieces of 10x10 mm were coatedwith hypromellose ointment containing one of the concentrations of C.citratus oil