A greenhouse trial, in which F. oxysporum served as model pathogens, was set up in order to monitor growth and disease development in tomato plants. S. flavofuscus strain CPP-53 was studied against F. oxysporum to reduce the effect of pathogen in soil medium. Disease severity was recorded following Grattidge and O'Brien (1982) using 0-4 scale system, four treatments were analysed with three replication of each treatment. Control (T 1 ) without pathogen was placed 0 in scale followed by T 2 ( F.oxysporum ) counted as dead plant (100%), T 3 ( S. flavofuscus Strain CPP-53 + F.oxysporum ) recorded as 1 (0-24%) and T 4 (CPP-53) recorded with no disease incidence with a plant growth promotion effect (Figure 3). When S. flavofuscus CPP-53 was inoculated alone, a significant increase in plant height and root volume was also achieved (Figure 4). The ability of Streptomycetes has been shown to be promising biocontrol agents capable of inhibiting fungal pathogens of several plant diseases.