Our
preliminary studies showed that both types of cells treated with
25 nM siRNA for 48 h could lead to .70% repression of CHOP
expression compared to those treated with control siRNA. These
cells were then treated with fucoidan (at 0 or 100 mg/ml) for 2 days
and CHOP expression and DNA damage (as assessed by cleaved
PARP) were analyzed. As shown in Fig. 7A,