The nutritional composition and anti-obesity activities of cereal bars containing Allium fistulosum
extract (AFB) in high-fat diet-induced obese mice was determined. AFB is rich in vitamins
C, B2, and B3, and B9 with high protein. Oral treatment of AFB in obese mice reduced
body weight, lipid accumulation in liver and adipose tissue as well as adipocyte size, compared
to the high fat diet control mice. AFB also decreased serum triacylglycerol, glucose,
and insulin concentrations, with increased HDL-cholesterol and adiponectin levels. Furthermore,
5% AFB markedly increased mRNA expression of peroxisome proliferators activated
receptor-c, uncoupling protein-2 as well as b3-adrenoreceptor in the visceral adipose tissue.
These results demonstrate that the cereal bar with A. fistulosum extract may potentially serve
as nutraceutical for improvement of obesity and metabolic disorders.