Despite comorbid depression being relatively common even in subjects with schizophrenia, to the best of our knowledge, there is, to date,
no report in the literature specifically and detailed examining the cognitive and clinical insight in subjects with schizophrenia and a comorbid
depressive syndrome. Hence, in this study, we sought to compare the cognitive and clinical insight in our subjects with schizophrenia with
and without a comorbid depressive syndrome. We found that participants in the depressive group scored significantly higher on selfreflectiveness
and the reflectiveness−certainty (R-C) index scores than those in the nondepressive group. There was no significant difference
among groups on the Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, and clinical insight
scores assessed by the Scale to Assess Unawareness of Mental Disorder. In addition, self-reflectiveness scores significantly correlated with
depression, observed depression, hopelessness, and suicidality subscores of the Calgary Depression Scale for Schizophrenia. A better
understanding of the cognitive component of insight in schizophrenia with comorbid depression may contribute to develop more efficient
cognitive strategies, thus improving patient outcome. However, clinicians should be aware of the possibility of exacerbating a sense of
hopelessness and suicide risk during the interventions that improve cognitive insight.