Psychotic and mixed affective episodes are prevalent in the course of bipolar disorder.
Despite many studies on the implications of psychotic mania (PM), psychotic depression (PD) and
mixed affective episodes (MAE), relatively little is known about the relationship between the three
subtypes. The present study aimed to investigate whether the occurrence of PM, PD and MAE were
associated with one another.
Methods:This is a nationwide register-based, historical prospective cohort study. Data was obtained
from the Danish Psychiatric Central Research Register. Subjects were defined as all individuals assigned
with an ICD-10 diagnosis of bipolar disorder between January 1st 1994 and December 31st 2010.
Potential associations among psychotic and mixed affective episodes were tested by means of logistic
regression