In this study, we evaluate the potential utility of a DSMS program equipped with a computer- assisted instructions (CAI) in a Thailand healthcare context. The program approaches were based on five major steps (the 5C intervention) of behavior change support ( Perot & Rubin,2007).The CAI was newly created by the research team in order to facilitate diabetes education. We conducted a cluster randomized controlled trial (CRT) incorporating the RE-AIM (Reach, Effectiveness , Adoption, Implementation ,and Maintenance) framework in order to determine the effectiveness of the DSMS program. This framework provided guidance for evaluating the potential of research into practice in "real-world" settings. In addition, it has also been used to understand the strengths and weaknesses of interventions (Bella et al.,2007;Bakken & Roland,2009;Glasgow et al.,2011). The results of this study may provide evidence-based for implementation and maintenance of a DSMS program into routine care for people with diabetes in Thailand, as well as in other developing countries.