Plasma lysozyme activity was significantly mals after 8 weeks of feeding, indicating that multi-species blend tenti probiotic (Bacillus sp., Pedicoccus sp., Enterococcus sp., Lactobacillus mere sp.) can stimulate this innate immune response in a dose and time dependent manner. Bacillus can stimulate lysozyme activity in estab l. However, association mechanisms seem to prod occur, since when Bacillus subtilis B. licheniformis were combined obse with Enteroccoccus faecium 16] or when were feed after a antibiotic 0.2 treatment 138]. lysozyme activity remained unaffected. Grouper Furth receiving B. pumilis or B. clausii presented an increased field l17], a pattern tive activity after 60 days of feeding but not after 30 days to ach similar to our observations. P acidilactici did not affect plasma the lysozyme activity, according to the observed in previous experi- ments in rainbow trout 1581 or channel catfish, alone or in combi I41] nation with E. faecium