Oxidative stress occurs when the generation of free radicals or reactive oxygen species (ROS)
exceeds the antioxidant capacity of a biological system. Excess free radicals and ROS attack biological molecules such as lipids, proteins and nucleic acids that lead to tissue or cellular injury. Oxidative stress has already been implicated in atherosclerosis, cancer, diabetes, arthritis, reperfusion damage and inflammation.
Antioxidants are free-radical scavengers that provide protection to living organisms from damage caused by ROS. Although almost all organisms possess antioxidant defense and repair systems but these systems are insufficient to cope over entire damage. So, dietary antioxidant supplementation is a promising mean to strengthen the antioxidant defense and repair systems. However, antioxidants from natural source are of great value as most commonly used synthetic antioxidants (e.g. butylatedhydoxyanisole, butylatedhydoxytoluene and propylgallate) have health hazardous side effects like liver damage and carcinogenesis. Centella asiatica (Linn.) Urban is a prostrate stoloniferous plant that belongs to the family Apiaceae and endogenous to Bangladesh. The therapeutic use of C. asiatica with its wide range of application has been documented in South East Asia and Bangladesh for centuries. C. asiatica is effectively being used in the treatment of fever, jaundice, dysentery, diarrhea, mental illness within the frame of traditional medicine of Bangladesh. Though several investigations showed antioxidant activity of C. asiatica but none of these explained the role of extraction solvent polarity on antioxidant potential. We, therefore, investigated in vitro antioxidant activity of C. asiatica and the impact of the extraction solvent polarity on antioxidant potential in this present study.
Oxidative stress occurs when the generation of free radicals or reactive oxygen species (ROS)
exceeds the antioxidant capacity of a biological system. Excess free radicals and ROS attack biological molecules such as lipids, proteins and nucleic acids that lead to tissue or cellular injury. Oxidative stress has already been implicated in atherosclerosis, cancer, diabetes, arthritis, reperfusion damage and inflammation.
Antioxidants are free-radical scavengers that provide protection to living organisms from damage caused by ROS. Although almost all organisms possess antioxidant defense and repair systems but these systems are insufficient to cope over entire damage. So, dietary antioxidant supplementation is a promising mean to strengthen the antioxidant defense and repair systems. However, antioxidants from natural source are of great value as most commonly used synthetic antioxidants (e.g. butylatedhydoxyanisole, butylatedhydoxytoluene and propylgallate) have health hazardous side effects like liver damage and carcinogenesis. Centella asiatica (Linn.) Urban is a prostrate stoloniferous plant that belongs to the family Apiaceae and endogenous to Bangladesh. The therapeutic use of C. asiatica with its wide range of application has been documented in South East Asia and Bangladesh for centuries. C. asiatica is effectively being used in the treatment of fever, jaundice, dysentery, diarrhea, mental illness within the frame of traditional medicine of Bangladesh. Though several investigations showed antioxidant activity of C. asiatica but none of these explained the role of extraction solvent polarity on antioxidant potential. We, therefore, investigated in vitro antioxidant activity of C. asiatica and the impact of the extraction solvent polarity on antioxidant potential in this present study.
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