Over the past decades, microfluidic technology has emerged as a powerful tool for intensifying heat and mass transfer processes. Advanced Flow Reactors (AFRs) are a type of microreactor that utilizes a unique heart-shaped unit design to achieve highly efficient mixing and mass transfer. One of the key factors that contributes to the effectiveness of AFRs is their ability to break bubbles into smaller sub-bubbles, which greatly increases the interfacial area and enhances the rate of mass transfer between the gas and liquid phases.