Steroid use in sepsis had a renaissance)
.[encouraged by a 2002 study by Annane and colleagues [26
This multicenter randomized clinical trial examined use of the
glucocorticoid hydrocortisone plus the mineralococorticoid
fludrocortisone in septic patients who did not respond to fluid
replacement and required use of vasopressors. In this population,
corticosteroids provided a survival advantage (hazard
ratio 0.67) and afforded an earlier wean from vasopressors
hazard ratio 1.91). There was no difference in the incidence)
of adverse events. SSC 2004 recommended the use of low dose
intravenous corticosteroids for septic patients who require
.vasopressors after fluid resuscitati