biocompatible, non-toxic, hemocompatible and mucoadhesive [18].
Alginate and chitosan are widely used to deliver therapeutic agents
such as peptides, proteins and polynucleotides. Entrapment in the
biopolymers maintains the physicochemical structure and pharmacological
activity of these agents and protects them from
enzymatic degradation [19]. Moreover, these formulations have
advantages including prolongation of the therapeutic agents in the
circulation, controlled release, reduced leaching, and the potential
for encapsulation of both hydrophilic and hydrophobic biomolecules
[18,20]. Therefore, alginate and chitosan biopolymers
have become important components in drug delivery systems.