Figure 4. Lysogenic lifestyles of gut microbiota phages. (A) The 59 end of phage contig MH0049.scaffold15669_1, which was assembled in sample
MH0049 (Danish individual), has a 99.5% identity in the sequenced genome of Bacteroides vulgatus ATCC 8482. (Block arrows) Genes; (cyan-colored
arrows) spacers matching the phage contig. (B) Coverage of phage contig MH0049.scaffold15669_1 byMetaHIT metagenomic reads from three samples.
(X-axis) Position on phage contig; (y-axis) read coverage (log scale). (Red curve) Coverage of VLP reads from Reyes et al. (2010). (C,D) Abundance of
phages MH0041.scaffold6276_1 and MH0009.scaffold32322_1 and their respective bacterial hosts in MetaHIT samples, indicative of lysogeny as
a preferred lifestyle. The x- and y-axes represent abundance of host and phage, respectively. Each data point represents a European individual sampled as
part of theMetaHIT gut microbiota project (Qin et al. 2010). Green-colored samples are the ones in which a spacermatched the phage sequence. ‘‘Phage
dominance’’ indicates samples where the phage is suspected to have become active. The correlation coefficient of phage and host abundances for samples
where both existed is 0.4 and 0.98, respectively.
Figure 4. Lysogenic lifestyles of gut microbiota phages. (A) The 59 end of phage contig MH0049.scaffold15669_1, which was assembled in sampleMH0049 (Danish individual), has a 99.5% identity in the sequenced genome of Bacteroides vulgatus ATCC 8482. (Block arrows) Genes; (cyan-coloredarrows) spacers matching the phage contig. (B) Coverage of phage contig MH0049.scaffold15669_1 byMetaHIT metagenomic reads from three samples.(X-axis) Position on phage contig; (y-axis) read coverage (log scale). (Red curve) Coverage of VLP reads from Reyes et al. (2010). (C,D) Abundance ofphages MH0041.scaffold6276_1 and MH0009.scaffold32322_1 and their respective bacterial hosts in MetaHIT samples, indicative of lysogeny asa preferred lifestyle. The x- and y-axes represent abundance of host and phage, respectively. Each data point represents a European individual sampled aspart of theMetaHIT gut microbiota project (Qin et al. 2010). Green-colored samples are the ones in which a spacermatched the phage sequence. ‘‘Phagedominance’’ indicates samples where the phage is suspected to have become active. The correlation coefficient of phage and host abundances for sampleswhere both existed is 0.4 and 0.98, respectively.
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