However, the diagnosis of asthma tends to be made on a history of recurrent or episodic attacks
of chest tightness, breathlessness and cough with
documented wheeze on auscultation of the chest
and obstructive defect on spirometry. In
immunological attention, asthma is characterized
by pulmonary infiltrates, eosinophilia, increased
levels of total IgE, and increased levels of antifungal
specific IgE, IgG and IgA antibody levels.
Treatment of patients with fungal asthma with
antifungals results in improved situation in these
patients, decreased IgE levels, and increased peak
flow. The current medication regimen of inhaled
corticosteroids, leukotriene antagonists, and longacting
beta-2 agonists is usually inadequate to
control severe asthma (Athari, 2013d).