Lipid nanoparticles with solid particle matrix are derived
from o/w emulsions by simply replacing the liquid lipid (oil) by
a solid lipid, i.e. being solid at body temperature. The first
generation of solid lipid nanoparticles (SLN) was developed at
the beginning of the nineties [1]. They were produced from a
solid lipid only. In the second generation technology of the
nanostructured lipid carriers (NLC), the particles are produced
by using a blend of a solid lipid with a liquid lipid, this blend
also being solid at body temperature [2].