There are indications, however, that this might be significant. Thus, Lphenylalanine benzyl ester,whichwas found to reduce sickling, appears to partition into the RBC membrane and non-specifically inhibits transport systems including the Na+/K+ pump, the cation cotransporters (probably the Na+–K+–2Cl− cotransporter, NKCC) and the anion exchanger
(AE1) whilst also increasing passive cation leaks. No information is available on the aromatic aldehydes.