Cyanide is a chemical compound that contains monovalent combining group CN. This group consists of a carbon atom triple- bonded to a nitrogen atom. Cyanide is considered to be toxic because it binds to cytochrome c oxidase ie. the fourth complex in the electron transport chain. It attaches to the iron within this protein complex and inhibits the normal activity of the complex system. It binds tightly so that it cannot transport any electrons to oxygen. This blocks the further passage of electrons throughout the chain, halting ATP production. Since no ATP is made, the electron transport chain stops working. This is so because the protons are not allowed to go back into the matrix of the mitochondria, thus, the concentration of protons build up and the gradient becomes large. Therefore, the person is deprived of chemical energy to perform the many numerous processes that sustain life and the person dies.
of blood agents (AC) and it was used in the Second WorldWar as
a weapon of mass destruction under the name of Zyklon B. Even
at present its ease of preparation and acute toxicity make this
product potentially dangerous as a terrorist weapon.2
Detection of cyanide in liquid samples has been achieved by
means of several methods. These include using electrochemical
sensors,3 polymers,4 gold nanoparticles,5 CdSe quantum dots,6
systems based on metal ion coordination,7 and organic fluorogenic
and chromogenic probes.8 Among these, colorimetric chemosensors
are of special interest because of their relatively low cost,
selectivity and the possibility of ‘‘naked-eye’’ detection, without the
use of expensive non-portable devices. Nevertheless, it is apparent
from the literature that many reported chromogenic chemosensors