The tablets were ground into a powder and a small amount of ethanol was added to help the grape seed extract dissolve in distilled water. Three concentrations of grape seed extract were defined on the basis of ARP, measured by means of the DPPH free radical scavenging method (Brand-Williams, Cuvelier, & Berset, 1995) with some modifications. Free radical DPPH (2,2-diphenyl-1-picrylhydrazyl from Sigma Aldrich Ltd., England) and grape seed extract were dissolved in ethanol.