Summary Essential oils are used in skincare products for perfuming and aromatherapy
purposes. In this study, the bioactivities of seven essential oils commonly
used and claimed for skincare namely citronella grass (Cymbopogon nardus L.),
lemongrass (Cymbopogon citratus DC), Kaffir lime (Citrus hystrix DC), holy
basil (Ocimum sanctum L.), sweet basil (Ocimum basilicum L.), plai (Zingiber cassumunar
Roxb) and ginger (Zingiber officinale Roscoe) were investigated. Investigation
of the in vitro susceptibility of the oils against Propionibacterium acnes (P.
acnes) using the broth microdilution technique revealed that citronella grass oil
exhibited the lowest minimum inhibitory concentration (MIC) and minimum bactericidal
concentration (MBC) at 0.005–0.3 and 0.6–1.2 ll/ml, respectively. The MIC
and MBC values of lemongrass oil were 0.6 ll/ml and those of kaffir lime oil and
holy basil oil were 5 ll/ml. Antioxidant activity using the DPPH free radical scavenging
assay showed that the IC50 values of holy basil oil (0.03 ll/ml), plai oil
(6.9 ll/ml) and citronella grass oil (2 ll/ml) were lower than that of ascorbic acid
(7.9 ll/ml). Anti-inflammatory activity of the oils determined using the 5-lipoxygenase
inhibition assay found that IC50 values of holy basil oil (0.04 ll/ml), kaffir
lime oil (0.05 ll/ml) and citronella grass oil (0.15 ll/ml) were less than that of
nordihydroquaretic acid (1.7 lg/ml). Since P. acnes has a role in the inflammation
of acne leading to scar formation, citronella grass oil may help to relieve acne
blemishes. However, further investigation in the form of clinical studies would
be necessary
Summary Essential oils are used in skincare products for perfuming and aromatherapypurposes. In this study, the bioactivities of seven essential oils commonlyused and claimed for skincare namely citronella grass (Cymbopogon nardus L.),lemongrass (Cymbopogon citratus DC), Kaffir lime (Citrus hystrix DC), holybasil (Ocimum sanctum L.), sweet basil (Ocimum basilicum L.), plai (Zingiber cassumunarRoxb) and ginger (Zingiber officinale Roscoe) were investigated. Investigationof the in vitro susceptibility of the oils against Propionibacterium acnes (P.acnes) using the broth microdilution technique revealed that citronella grass oilexhibited the lowest minimum inhibitory concentration (MIC) and minimum bactericidalconcentration (MBC) at 0.005–0.3 and 0.6–1.2 ll/ml, respectively. The MICand MBC values of lemongrass oil were 0.6 ll/ml and those of kaffir lime oil andholy basil oil were 5 ll/ml. Antioxidant activity using the DPPH free radical scavengingassay showed that the IC50 values of holy basil oil (0.03 ll/ml), plai oil(6.9 ll/ml) and citronella grass oil (2 ll/ml) were lower than that of ascorbic acid(7.9 ll/ml). Anti-inflammatory activity of the oils determined using the 5-lipoxygenaseinhibition assay found that IC50 values of holy basil oil (0.04 ll/ml), kaffirlime oil (0.05 ll/ml) and citronella grass oil (0.15 ll/ml) were less than that ofnordihydroquaretic acid (1.7 lg/ml). Since P. acnes has a role in the inflammationof acne leading to scar formation, citronella grass oil may help to relieve acneblemishes. However, further investigation in the form of clinical studies wouldbe necessary
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